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 Ⅰ.Synthetic chemistry

(1) R&D center, Haimen, Jiangsu:   R&D center of Wisdom Pharmaceutical is located in Haimen, Jiangsu Province. There are a number of synthesis labs, including one specialized in fluorine chemistry, which totally can a-
ccommodate more than 100 synthetic chemists. In addition to the synthesis labs, kilo- lab wi-
th glass jacketed reactors (10L to 30L) and pilot workshop (clean room included) under the G-
MP condition with 20L to 200L reactors for small amount production are also equipped.

(2) Compound library:     Based on our understanding and knowledge of medicinal chemistry, we designed and sy-
nthesized compound library. The annual production of the library is tens of thousands of co-
mpounds, each compound with a quantity more than 20mg, and purity more than 90%.

  Ⅱ.Process R&D

   (1) Wisdom Pharmaceutical has a world-class experienced synthetic chemistry leadership te-
am together with dozens of synthetic chemists. We can provide customers with one-stop contr-
act synthesis service (CRO + CMO + GMP), and meet the customer's growing demand for dru-
gs, from the lab test sample to the commercial production, thus ensuring the smooth progress of clinical trials and commercialization of customers. Our professional process R&D team can qui-
ckly develop a feasible and efficient chemical synthetic route for the customer, and figure out th-
e key issues of the synthetic chemistry then provide the most efficient solution.

   (2) We have completed hundreds of target compounds (from kilograms to tons) for customers, with an average of more than seven-step synthetic route, the successful completion rate is abov-
e 95%. In order to ensure the quality, our organic synthesis team keeps close communication a-
nd cooperation with Quality department, conducting a complete inspection to every product bef-
ore shipping out. So we are well received by our customer's praise.